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Bad/In depth Metabolizers, CYP2D6 The development with the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately 7% with the inhabitants has minimized exercise of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These men and women are “very poor metabolizers” of debrisoquine, dextromethorphan and